معرفی
Lea A. Goentoro is a Professor of Biology at the California Institute of Technology (Caltech), affiliated with the Division of Biology and Biological Engineering. Her research focuses on systems biology, signaling pathways, and developmental mechanisms, with a particular emphasis on understanding how biological systems achieve robustness and adaptability. She holds a B.S. from the University of Wisconsin-Madison (2001) and a Ph.D. from Princeton University (2006). Before becoming a full Professor at Caltech in 2018, she served as an Assistant Professor there from 2011.
Goentoro's lab investigates diverse biological systems, including jellyfish regeneration, developmental symmetry, and signaling pathway dynamics. Key research areas include relative perception in signaling pathways (e.g., Wnt and TGF-β), robustness in embryonic development, and the molecular mechanisms underlying regeneration. Her work combines mathematical modeling, biochemical experiments, and interdisciplinary approaches to uncover design principles in biological systems.
Her team has made significant contributions, such as demonstrating fold-change detection in the Wnt pathway and identifying self-repair mechanisms in jellyfish. Collaborations include studies on sleep-like behavior in jellyfish and symbiotic development in early metazoans. Current projects explore transcriptional regulation in Wnt pathways, mechanosensing in regeneration, and cellular computations involving logarithmic sensing.
Goentoro has mentored numerous students and postdocs, including alumni now in academia and industry. Her lab actively seeks creative researchers and technicians for projects in regeneration biology and systems biology. She is also involved in the Systems Biology Program at Caltech, fostering interdisciplinary research.
