Lawrence T. Feldman

Dr. Lawrence T. Feldman is a Professor in the Department of Microbiology, Immunology & Molecular Genetics at the University of California, Los Angeles. His research focuses on the molecular mechanisms of Herpes Simplex Virus (HSV) type 1 latency, particularly in neuronal environments.

• Affiliation: Member of the Immunity, Microbes & Molecular Pathogenesis Graduate Program at UCLA

Research Interests:
Feldman's laboratory specializes in HSV-1 latency, investigating the LAT (latency-associated transcript) promoter, transcription factor binding sites (e.g., TAATGARAT sequences), and viral DNA repression mechanisms. Key projects include mapping neuronal transcription factors in mouse models, analyzing cDNAs/PCR products in the LAT region, and exploring HSV-1 as a gene delivery vector for neurons.

Publication Trends:
His recent work (1997–2002) emphasizes HSV-1 transcriptional regulation, latency-associated promoter dynamics, and the interplay between viral latency and host immune responses. Subfields span neurovirology, viral genetics, and molecular pathogenesis.

Laboratory Focus:
The team investigates how HSV-1 establishes and maintains latency through genomic elements like TAATGARAT sequences, aiming to develop viral vectors for targeted neuronal gene expression.