معرفی
Laurent Debarbieux is a Researcher at the Pasteur Institute in Paris, France, affiliated with the Microbiology department. His work focuses on bacteriophage biology, phage therapy, and host-pathogen interactions.
- Current projects include:
- PHAGESAFETY (blood marker identification for phage toxicity)
- VHRdb (Viral Host Range database development)
- Phage-host molecular dynamics in Pseudomonas aeruginosa and Escherichia coli
Research highlights:
His studies explore phage therapy optimization through automated potency assays, biofilm disruption, and genotype-dependent resistance mechanisms. He investigates phage-plasmid coevolution, archaeal virus-host equilibrium, and spatio-temporal infection dynamics using gnotobiotic mouse models and high-throughput sequencing.
Collaborative networks:
- Key collaborations with Jean-Marc Ghigo, Jean-Daniel Lelièvre, and Joshua S. Weitz
- Partnerships with Genoscope and MicroScope/MaGe platforms
Methodological expertise:
- Cryo-electron tomography for virion assembly visualization
- RNA-Seq and NGS variant detection
- Development of automated pipetting protocols for phage testing
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