معرفی
Laurence Mulard is a leading researcher at the Institut Pasteur in Paris, France, where she serves as Head of Structure and Principal Investigator in the Carbohydrates and Bioconjugates group under the Dynamics of Host-Pathogen Interactions. She is based in the Unité de Chimie des Biomolécules and leads multiple cutting-edge projects at the intersection of glycobiology, organic chemistry, and vaccinology.
- Position: Head of Structure, Principal Investigator
- Institution: Institut Pasteur
- Research Unit: Unité de Chimie des Biomolécules
- Research Group: Carbohydrates and Bioconjugates
- Focus Areas: Glycoconjugate vaccines, synthetic carbohydrate chemistry, host-pathogen interactions, diagnostics
Her research centers on the design and synthesis of synthetic carbohydrate-based conjugate vaccines, particularly targeting Shigella species causing shigellosis. She pioneered the development of SF2a-TT15, the first-in-human synthetic glycan-based conjugate vaccine candidate against Shigella flexneri 2a, which has demonstrated safety and immunogenicity in clinical trials. Her work also extends to Alzheimer's disease diagnostics via protein conjugates and explores chemical probes and therapeutic conjugates. She employs multidisciplinary strategies combining chemical synthesis, enzymatic engineering, and immunological evaluation.
The most recent 15 publications highlight a consistent focus on glycoconjugate vaccine development, structural analysis of complex glycans, and synthetic methodologies for bacterial oligosaccharides. Key themes include the scalable synthesis of vaccine candidates, chemoenzymatic diversification of glycan structures, and the transition from preclinical to clinical evaluation of synthetic vaccines. Her work bridges fundamental chemistry with translational applications in infectious disease prevention.
- GlycoShig1: Synthetic carbohydrate-based conjugates as Shigella vaccine components
- CarbUniVax: Multidisciplinary project at the frontier of Glycosciences and Vaccinology
- FlexBiVac: Proof of concept for multivalent polysaccharide-based vaccines
- Synthesis of peptide-protein conjugates for therapeutics and diagnostics
Laurence Mulard actively mentors PhD students and post-doctoral researchers, contributing to the next generation of scientists in glycosciences and vaccinology. She has secured significant research funding and led projects under GMP conditions, resulting in clinical-grade vaccine batches. Her team includes research engineers, technicians, and students, reflecting a robust and collaborative research environment.
She is associated with key institutional initiatives including the Center for Vaccinology and Immunotherapy (CVI) and the Drug Discovery & Screening at Institut Pasteur (ATC-DDS), positioning her work within broader therapeutic development efforts. Her laboratory is equipped with advanced instrumentation such as an NMR spectrometer (Bruker Avance 400 MHz), supporting structural characterization of complex molecules.
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