معرفی
Laura de Rooij is a Principal Investigator at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences since September 2022. Her research combines single-cell omics with functional vascular assays to characterize endothelial cell heterogeneity in health, aging, and disease contexts.
- University of Amsterdam - Biomedical Sciences graduate
- McMaster University - RNA-binding protein research in leukemia
- VIB-KU Leuven - Postdoctoral work in angiogenesis and vascular metabolism
- CeMM - Lab leader since 2022
Research focus areas:
- Endothelial cell aging mechanisms across organs
- Disease-associated vascular rewiring in conditions like COVID-19 and cancer
- Development of 3D culture systems including vessel-on-chip platforms
- CRISPR-based functional interrogation of molecular circuitries in endothelial dysfunction
Key publications highlight:
- Characterization of lipid-processing endothelial subtypes in breast cancer
- Identification of profibrotic endothelial phenotypes in pulmonary fibrosis
- Advances in single-cell transcriptome atlases across tissues
- Development of organotypic human endothelial models using iPSCs
Laboratory resources:
- Lab website maintaining research continuity
- 3D culture platforms for EC functional analysis
- Collaborative networks across European research institutes
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