معرفی
Dr. Lars E. P. Dietrich is a Professor at Columbia University, leading a research group focused on bacterial biofilm physiology and antibiotic resistance. His lab investigates how cellular arrangement in biofilms influences metabolic gradients and antimicrobial susceptibility, primarily using Pseudomonas aeruginosa as a model system.
Research explores biofilm microanatomy, substrate distribution, and genetic determinants of cellular patterning. Key findings demonstrate that ordered cellular arrangements create metabolic subzones that determine antibiotic penetration, while mutations disrupting cell-surface components alter susceptibility profiles. The lab employs advanced imaging techniques including SEM and stimulated Raman scattering microscopy.
Collaborations span Columbia Chemistry, University of Chicago, and CUNY, integrating expertise in biophysics and bacterial genetics. Current projects examine implications for treating chronic infections caused by biofilm-forming pathogens.
