معرفی
Lalit Pukhrambam is an Associate Professor in the Department of Ophthalmology, Visual and Anatomical Sciences at Wayne State University School of Medicine. He holds a Ph.D. in Biochemistry from the Indian Institute of Science, Bangalore, India. His research investigates diabetic retinopathy mechanisms, emphasizing mitochondrial dysfunction, oxidative stress, and TXNIP-mediated inflammasome activation. Current work is supported by NIH/NEI R01 grant EY023992, with prior funding from the American Diabetes Association and JDRF.
Research Focus: Dr. Pukhrambam explores TXNIP's role in mitochondrial quality control, mitophagy, NLRP3 inflammasome signaling, and epigenetic regulation in diabetic retinopathy. His lab employs RNAi, CRISPR/Cas9, and gene therapy approaches to develop neurovascular protective strategies. Key areas include redox imbalance, ferroptosis, and metabolic dysregulation in retinal cells.
Publication Trends: Recent articles emphasize mitochondrial bioenergetics, barrier dysfunction diagnostics (e.g., ECIS technology), and combination therapies targeting mitophagy. Interdisciplinary themes span molecular pharmacology, epigenetics, and neurodegenerative cross-talk in ocular diseases.
Grants & Labs: Primary funding via NIH/NEI supports research on TXNIP-mediated mitochondrial retrograde signaling. Lab activities focus on in vitro retinal models (endothelial/pericyte/Müller cells) and in vivo diabetic rodent studies using streptozotocin induction.
