معرفی
Dr. Lajos Pusztai is a Professor of Medicine at Yale University and Scientific Co-Director of the Breast Center at the Yale Cancer Center. He holds leadership roles including Co-Director of the Genetics, Genomics, and Epigenetics Program and chairs the Breast Cancer Research Committee of SWOG. His research focuses on breast cancer subtypes, genomic profiling, and clinical trials for targeted therapies. He has authored over 250 publications, including work in high-impact journals like NEJM and Lancet Oncology. Dr. Pusztai received his MD from Semmelweis University and D.Phil. from Oxford University.
Education:
- Medical Degree: Semmelweis University School of Medicine (1987)
- D.Phil.: University of Oxford (1993)
- Residency: University of Rochester St. Mary's Hospital (1996)
- Fellowship: University of Texas MD Anderson Cancer Center (1999)
Research Interests:
His work established key distinctions between estrogen receptor-positive and-negative breast cancers, pioneered gene expression profiling for treatment prediction, and developed tools like Residual Cancer Burden (RCB) scoring. He leads clinical trials for immunotherapies and novel drug combinations, emphasizing personalized cancer care.
Key Contributions:
- Clarified clinical value of neoadjuvant chemotherapy in breast cancer subtypes
- Developed RCB metric for post-therapy assessment
- Advanced biomarker-driven therapy through genomic studies
Awards:
- Clinical Science Research Prize (2022)
- Top 1% Highly Cited Investigator (2015)
Advising & Grants:
Leads multiple clinical trials (e.g., I-SPY2, NA-PHER2) and collaborates with institutions globally. His team includes prominent researchers like David Rimm and Kim Blenman. Grants focus on translational research and clinical trial innovation.
Labs & Teams:
Pusztai Lab Subset Medical Oncology Group at Yale Cancer Center, focusing on breast cancer genomics and clinical translation.
