معرفی
Kyle Vining, D.D.S., Ph.D. is an Assistant Professor at the University of Pennsylvania, holding dual appointments in the School of Dental Medicine (Department of Preventive and Restorative Sciences) and the School of Engineering & Applied Sciences (Department of Materials Science). He leads the Vining Lab, focusing on mechanical regulation of tissue inflammation in bone marrow disease and head/neck cancer, and develops biomaterials for dental regeneration.
- Education:
- B.S. in Biomedical Engineering, Northwestern University (2005-2009)
- D.D.S., University of Minnesota School of Dentistry (2009-2014)
- Ph.D. in Engineering Sciences (Bioengineering), Harvard University (2014-2020)
- Postdoctoral Scientist in Medical Oncology, Dana-Farber Cancer Institute (2021-2022)
Research Interests center on:
- Mechanical cues in fibrotic and cancer microenvironments
- Antimicrobial coatings for titanium implants
- Polymeric materials supporting dental pulp stem cell regeneration
- Immunoengineering via viscoelastic matrix modulation
- High-throughput biomaterials screening
- STING pathway activation for oral cancer therapy
Publication Trends since 2017 span Nature Materials, Nature Biomedical Engineering, PNAS, and Advanced Materials, emphasizing biomaterials, mechanotransduction, and stem cell immunomodulation. Key topics include hydrogel viscoelasticity, extracellular matrix mechanics, and mechanical checkpoint regulation in disease.
- Scientific Awards
- NIH K99 (2021) and K08 (2016) grants
- Councilor, IADR Oral Surgery Research Group (2021-2023)
- AADOCR Hatton Competition Senior Category First Place (2021)
- Royal Society of Chemistry Emerging Technologies Second Place (2016)
- Harvard University Teaching Fellow (2016)
- Multiple student awards (IADR Hatton, Wrigley Salivary Research, etc.)
Notable Grants & Collaborations include NIH/NIDCR-funded projects addressing mechanical regulation of monocyte fate and anti-inflammatory stem cell therapies. His work bridges the Vining Lab (Penn Dental) with cross-disciplinary teams at Harvard, Dana-Farber, and industry partners.
Laboratory Site: The Vining Lab focuses on mechanobiology-driven dental and craniofacial regeneration.
