معرفی
Dr. Ksenia Gnedeva is an Assistant Professor at the Keck School of Medicine of USC, holding dual appointments in the USC Caruso Department of Otolaryngology – Head and Neck Surgery and the Department of Stem Cell Biology and Regenerative Medicine. Her research focuses on molecular and mechanical mechanisms governing sensory organ development and regeneration, particularly in the inner ear and retina. She investigates signaling pathways (e.g., Hippo, Yap/Tead) and tissue mechanics to understand how developmental programs can be reactivated post-injury for hearing and balance restoration. Her lab identified key regulators like p27Kip1 and Atoh1 enhancers, targeting these pathways to unlock regenerative potential. She earned her Ph.D. in developmental and cell biology from Sanford Burnham Prebys Medical Discovery Institute and Koltsov Institute, and is a member of the Hearing Restoration Project.
Research Interests: Molecular signaling pathways (e.g., Hippo, YAP), tissue mechanics, inner ear regeneration, retinal regeneration, and epigenetic regulation of sensory cell differentiation. Her work bridges developmental biology and regenerative medicine to address hearing loss and vision impairment.
Lab Activities: The Gnedeva Lab develops organoid models, employs CRISPR-based tools, and tests pharmacological inhibitors to target regeneration-suppressing pathways. Recent studies include identifying shared genes in hearing and vision regeneration across species (e.g., zebrafish, lizards) and exploring nephron progenitor cells for kidney disease modeling.
Publications Trends: Recent work emphasizes Hippo/YAP pathway modulation, epigenetic control of sensory competence, and translational applications like cochlear hair cell detection datasets. Her research spans from basic molecular mechanisms to preclinical therapeutic strategies.
