Krüger

Prof. Dr. Krüger is a faculty member at the University of Greifswald, affiliated with the University Medicine Greifswald. Their research focuses on proteostasis regulation via the ubiquitin-proteasome system (UPS) in both physiological and pathological contexts.

The group investigates how UPS disturbances intersect with immune responses and oxidative stress, contributing to diseases like autoinflammatory disorders, tumors, neurodegeneration, and infections. Funding is provided by the German Research Foundation (DFG) and the Thyssen Foundation.

Key research areas include:

• Ubiquitin-Proteasome System (UPS)
• ERAD pathway
• Antigen presentation to cytotoxic T cells
• Redox signaling and antioxidant defense
• Translational approaches in molecular medicine

Their publications highlight UPS roles in oxidative stress cytotoxicity, proteasome mutations in CANDLE/PRAAS syndromes, and Nrf1-dependent proteasome regulation.

Contact: +49 (0) 3834 86-5401