Kirill Kiselyov

Kirill Kiselyov is an Associate Professor in the Department of Biological Sciences at the University of Pittsburgh’s Kenneth P. Dietrich School of Arts and Sciences. His research focuses on ion channel function, lysosomal biology, and cellular degradation pathways, with particular emphasis on lysosomal storage diseases and their implications in cancer and neurodegenerative disorders. He leads a lab investigating how cells monitor and respond to disruptions in the endocytic pathway, leveraging genetic and pharmacological approaches to identify therapeutic targets.

Key research themes include the role of TRPML1 channels in lysosomal calcium signaling, autophagy-lysosomal dysfunction in disease, and the interplay between lysosomal and mitochondrial systems in cancer progression. His lab employs diverse models, including human cancer cells, Drosophila, and mouse models, to study these mechanisms. Kiselyov’s work bridges basic cellular biology with translational research, aiming to develop novel treatments for conditions like mucolipidosis IV and head and neck cancers.

His articles highlight advancements in understanding lysosomal-exocytosis regulation, PRMT inhibitor applications in cancer therapy, and the pathophysiology of genetic disorders linked to ion channel dysfunction. Collaborative efforts include studies on drug sensitivity modulation and biomarkers for cellular stress responses. Kiselyov actively engages in education through innovative pedagogical approaches, such as peer-reviewed presentation exchanges in undergraduate classrooms.