Kenneth Westover

Dr. Kenneth Westover is an Associate Professor of Radiation Oncology and Chief of Lung Radiation Oncology Service at UT Southwestern Medical Center. He also serves as co-director of the Simmons Comprehensive Cancer Center’s thoracic disease-oriented team and Director of Clinical Innovation and Information Systems in the Department of Radiation Oncology. His research focuses on developing targeted therapies for RAS and kinase-driven cancers, with breakthroughs in KRAS G12C inhibitors influencing FDA-approved drugs like sotorasib and adagrasib. Clinically, he innovates software tools for radiation oncology operations and explores adaptive radiation techniques for lung cancer patients, including SAbR/SBRT fraction timing optimizations and MRI-guided systems. He leads the Westover Lab, integrating protein chemistry, structural biology, and informatics to advance oncology therapies.

Education:

• Bachelor’s in Biochemistry, Brigham Young University
• Ph.D. and M.D., Stanford University
• Radiation Oncology Residency, Harvard Radiation Oncology Program

Research Interests:

• Targeted therapy development for RAS and kinase mutations
• Mechanistic studies of RAS signaling and drug resistance
• Adaptive radiation therapy strategies for lung cancer
• Clinical innovation in radiation oncology operations

Advising & Grants: Leads the Westover Lab, directing multidisciplinary teams in drug discovery and clinical innovation. Oversees clinical software implementations (e.g., RO-PAD, EPIC integration) and manages grants focused on translational oncology and radiation therapy optimization.

Labs/Teams: The Westover Lab at UT Southwestern, collaborating with Simmons Comprehensive Cancer Center and Harvard-affiliated institutions.