معرفی
Kelly Nguyen is a Researcher at the Molecular Immunity Unit of the University of Cambridge, affiliated with the MRC Laboratory of Molecular Biology (LMB). Their work focuses on elucidating the molecular architecture and regulation of telomerase, a critical enzyme for maintaining chromosome stability, and related processes in telomere biology.
- Research Focus: Telomere maintenance mechanisms, human telomerase holoenzyme structure, and implications for diseases like cancer and premature aging syndromes.
- Methodology: Integrated structural biology approaches (biochemistry, cryo-EM) combined with in vivo studies in mammalian cells.
Their recent publications highlight structural insights into telomerase dimerization, recruitment, and DNA interactions, as well as spliceosomal complexes. Key trends include:
- Deciphering telomerase assembly and regulation via high-resolution cryo-EM.
- Investigating RNA-mediated processes (e.g., LINE-1 retrotransposition) and protein-DNA interactions critical for genome integrity.
Group members include researchers contributing to structural studies and functional analyses of telomere biology.
۰مقاله ثبتشده
