Keith Nehrke

Dr. Keith Nehrke is a Professor in the Department of Medicine, Nephrology at the University of Rochester School of Medicine and Dentistry. His research integrates physiology and genetics to study molecular mechanisms linking bioenergetic responses to metabolic plasticity, survival, and behavior in whole organisms.

• PhD in Biochemistry, University of Rochester School of Medicine and Dentistry
• Postdoctoral training at the Center for Oral Biology, University of Rochester Medical Center

Dr. Nehrke's research focuses on mitochondrial ion flux, proteostasis, and trans-organelle signaling pathways that regulate hypoxic sensitivity. He utilizes genetic model organisms like Caenorhabditis elegans and translates findings to mammalian models such as mice. His work emphasizes collaboration and innovative tools like CRISPR-Cas9 genome editing.

Recent studies from his lab highlight connections between tau phosphorylation, mitochondrial dysfunction, and Alzheimer's disease, alongside metabolic remodeling in corneal fibrosis. Publications span disciplines including neuroscience, cell biology, and ophthalmology.

His laboratory explores how mitochondrial quality control mechanisms and potassium channels contribute to cardioprotection and stress response. Collaborative efforts include investigations into ischemic preconditioning and age-related metabolic changes.