Kathryn Miller-Jensen

Kathryn Miller-Jensen is an Associate Professor of Biomedical Engineering at Yale University with affiliations across multiple departments and research centers including the Yale Cancer Center, Yale Center for Systems and Engineering Immunology (CSEI), Computational Biology and Biomedical Informatics, Immunology, and Molecular Cell Biology, Genetics and Development.

Dr. Miller-Jensen's research program focuses on quantitative, systems biology approaches to studying changes in intracellular signaling, particularly after viral infection. Her laboratory investigates immune cell heterogeneity with a focus on macrophage innate immune cells, which are critical for healthy tissue function and important emerging targets for cancer immunotherapy. She also studies the role of cell-to-cell heterogeneity in latent HIV infection in T cells.

Her lab employs a systems immunology approach, combining quantitative experiments with computational analyses to study the multiple molecular and cellular processes that enable robust immune regulation. Recent publications demonstrate her focus on macrophage communication behavior, regulatory logic of signal-response relationships, and development of micro-chip devices for single-cell analysis. Her work bridges engineering, biology, and computational science to address fundamental questions in immunology with applications to cancer and infectious disease.

Dr. Miller-Jensen collaborates extensively with researchers across Yale, including Prof. Rong Fan in Biomedical Engineering, Prof. Paul Turner in Ecology and Evolutionary Biology, and numerous cancer researchers through the Yale Cancer Center. She has received significant funding including an NCI U01 contract grant for developing single-cell analysis technologies applicable to cancer research.

The Miller-Jensen laboratory provides training opportunities for students through the Yale Combined Program in the Biological and Biomedical Sciences (BBS) and the Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative, fostering the next generation of researchers at the interface of engineering and biology.