معرفی
Kathryn Lilley is a Professor in the Department of Biochemistry at the University of Cambridge, affiliated with the Cambridge Centre for Proteomics and the Milner Therapeutics Institute. Her research focuses on developing and applying proteomic technologies to study the dynamic proteome and transcriptome in cells, including spatial proteomics and RNA-protein interactions. Her work addresses mechanisms of cellular processes such as differentiation, stress responses, and disease.
Her research group develops methods for high-throughput measurement of protein abundance, localization, post-translational modifications, and interactions. Key areas include studying the spatial distribution of the transcriptome, RNA-protein complexes, and the interplay between proteome and transcriptome dynamics. Collaborations with academic and industrial partners enhance applications in drug discovery and disease modeling.
Key methodologies include hyperLOPIT, LOPIT-DC, and orthogonal organic phase separation (OOPS) for comprehensive proteomic and transcriptomic analysis. Lilley’s group also explores the functional implications of protein localization and RNA-protein interactions in contexts like cancer, metabolic disorders, and viral infections.
