معرفی
Kate Zaytseva is an Associate Professor in the Department of Toxicology and Cancer Biology at the University of Kentucky, and serves as Associate Director of Graduate Studies. She is affiliated with the Markey Cancer Center. Her research focuses on lipid metabolism in colorectal cancer (CRC), particularly the role of Fatty Acid Synthase (FASN) in tumor progression and metastasis. Her work explores therapeutic strategies targeting de novo lipogenesis and metabolic vulnerabilities in cancer cells.
Education: PhD in Pharmacology from the University of Kentucky, with prior degrees from Rostov State University (Russia) and North Caucasus Personnel Center (Russia).
Research Interests: Investigating FASN's role in CRC metastasis, sphingolipid metabolism regulation, CD36's contribution to metastasis, and FASN inhibition in preclinical models. Her lab uses patient-derived xenografts and genetically modified mouse models to evaluate therapeutic efficacy and biomarkers.
Key Projects: 1. FASN inhibition in PDX models and biomarker identification; 2. Sphingolipid metabolism mechanisms; 3. CD36 regulation and therapy resistance; 4. FASN-driven CRC in mouse models.
Publications Highlight: Recent work emphasizes FASN's role in tumor metabolism, drug resistance, and environmental toxin effects on cancer. Articles span 2007–2025, with a focus on lipid metabolism, metastasis, and translational therapeutics.
Advising/Grants: Leverages collaborations and institutional resources to advance preclinical research. Her work bridges basic science and clinical applications in cancer therapy.
Labs/Teams: Leads a research group focused on metabolic pathways in CRC at the University of Kentucky.
