Kate Miroshnikova

Dr. Kate Miroshnikova leads the Biophysical Regulation of Cell State Dynamics lab at the University of Münster, affiliated with the Cells in Motion Interfaculty Centre and Collaborative Research Center 1348. Her interdisciplinary research integrates biophysics, cell biology, and engineering to study how mechanical forces regulate chromatin architecture, nuclear dynamics, and cell fate decisions.

• Lab focus: Mechano-osmotic environments, macromolecular crowding, and nuclear shape abnormalities in cancer
• Methodology: 2D/3D in vitro models, organoids, mouse models, bioreactors

Research emphasizes mechanosensitive checkpoints in genome integrity, mechanochemical feedback loops, and nuclear deformation mechanisms with implications for DNA damage protection and aging. Key findings include the role of chromatin-lamina interfaces in aging/cancer and dynamic coupling of cellular position with fate in multilayered tissues.

Contact:

• Email: kate@mpi-muenster.mpg.de
• Phone: +49 251 70365-350
• Follow on Bluesky: @katemiro.bsky.social