معرفی
Kate McDole is a Researcher at the MRC Laboratory of Molecular Biology, University of Cambridge. Her lab focuses on understanding how mechanical forces shape early mammalian embryos, combining live-imaging, genetics, and computational tools to study tissue morphogenesis at single-cell resolution.
Her research investigates the transformation of simple cell populations into complex structures like the gut tube and heart, emphasizing the coordination of mechanical forces with gene expression. She pioneered an advanced light-sheet microscope to visualize post-implantation mouse development over multiple days, enabling detailed analysis of cell fate and tissue dynamics.
The lab's work includes video demonstrations of their imaging systems and specific studies on cardiac and foregut development. Their publications highlight innovations in embryonic imaging and lineage analysis.
Group members include Sonia Agüera Gonzalez, Katharine Goodwin, Jenny Kretzschmar, Ewa Paluch, and Henry Westmacott. Future goals involve creating a comprehensive force-map of embryogenesis to improve synthetic tissue engineering.
