معرفی
Karoline Sanches is a Research Fellow in the Department of Medicinal Chemistry at Monash University. Her work focuses on structural biology and the functional analysis of peptides derived from marine organisms, particularly sea anemones, and their interactions with ion channels.
Research Interests: Utilizing structural biology techniques to understand conformational dynamics in peptide toxins, their binding mechanisms to voltage-gated potassium channels (KV1.3), and applications in drug design and molecular modeling. Her research spans biochemistry, pharmacology, and computational biology.
Key Research Trends: Recent work highlights the study of ShKT domain peptides, marine-derived compounds targeting ion channels, and structural insights into therapeutic lead binding. Collaborations with researchers in molecular dynamics and computational modeling are central to her contributions.
Education & Affiliation: Affiliated with Monash University, specializing in Medicinal Chemistry. No explicit educational details provided in the text.
Collaborations: Collaborators include R.S. Norton (senior author), D.C.C. Wai, K.G. Chandy, and others. Contributions span peer-reviewed articles and reviews in journals like BBA Proteins and Proteomics, Journal of Chemical Information and Modeling, and Toxicon.
