معرفی
Karla M Neugebauer is the R. Selden Rose Professor of Molecular Biophysics and Biochemistry and Professor of Cell Biology at Yale School of Medicine. She directs the Yale Center for RNA Science and Medicine since 2018. Her research focuses on RNA metabolism, co-transcriptional splicing, and Cajal body dynamics. Neugebauer holds a BS from Cornell University and PhD from UCSF, with postdoctoral training at Fred Hutchinson Cancer Research Center and Max Planck Institute.
- Education: BS Biology (Cornell, 1984); PhD Neuroscience (UCSF, 1990)
Research interests span RNA biology mechanisms, including splicing regulation, nuclear speckles, and membraneless organelles. Her lab pioneered techniques linking imaging, genomics, and sequencing to study RNA processing. Notable achievements include discovering co-transcriptional splicing prevalence and identifying coilin's essential role in zebrafish development.
Recent work bridges fundamental biology with climate challenges, advocating biochemical solutions for planetary health. Over 90 publications span Nature Reviews Cancer, Molecular Cell, and Cell Biology journals. Awards include RNA Society's Mid-Career Prize (2017) and EMBO membership (2012).
- Awards: Mid-Career Achievement Award (2017), CASE Member (2016), EMBO Member (2012)
Advising includes mentoring students like Prajwal Boddu (MD/PhD) and Matt Simon (PhD). Active in Yale's Climate & Diversity initiatives and serves on admissions committees. Lab members recently secured grants from Yale Planetary Solutions for hydrofluorocarbon destruction projects.
Led development of the PYME nanoscopy platform and co-founded the BQBS graduate track. Current projects explore SF3B1 mutation impacts on chromatin and RNA granules in myeloid cancers.
