Karl-Friedrich Becker

Prof. Dr. Karl-Friedrich Becker is a distinguished academic at the Technical University of Munich (TUM) within the TUM School of Medicine and Health. His primary field of expertise is Experimental Pathology, with a focus on cancer genomics, molecular diagnostics, and biobanking infrastructure. He leads research on tumor biology, biomarker discovery, and standardization of pre-analytical processes in clinical and research settings.

Becker has contributed significantly to understanding the molecular mechanisms of cancers such as breast, esophageal, and colorectal cancers. His work includes developing novel tissue fixation methods (e.g., PAXgene) to preserve protein integrity for diagnostic and research purposes. He also pioneered initiatives like the BarrettNET registry to assess progression risks in Barrett's esophagus patients and co-authored key papers on pan-cancer genomic analyses through The Cancer Genome Atlas (TCGA).

• Key Projects: GENESIS study on genetic biopsy predictions, SPIDIA morphology ring trials for tissue fixation validation
• Biobanking Leadership: Federated biobank systems (e.g., Munich Biobank Alliance) and European infrastructure initiatives
• Proteomic Expertise: Reverse Phase Protein Arrays (RPPA) for clinical biomarker assessment

His research emphasizes translational applications, bridging basic science and clinical practice through standardized protocols. Over 150 peer-reviewed publications reflect his leadership in oncology, pathology, and biomedical research methodologies.