معرفی
Prof. Karima Djabali is a Professor of Epigenetics of Skin Aging at the TUM School of Medicine and Health, affiliated with the Department of Dermatology and Allergology and the Central Institute of Medical Technology. Her research focuses on premature aging syndromes, particularly Hutchinson-Gilford Progeria Syndrome (HGPS), investigating stem cell biology, tissue regeneration, and molecular pathogenesis. She has held academic positions at Columbia University (USA), EMBL Heidelberg, and CNRS, and earned her doctorate at the Rockefeller University under Nobel laureate Prof. Guenter Blobel.
Education:
- Biochemistry studies at Université Paris 7
- PhD in Biology at Collège de France and Rockefeller University
Research interests emphasize cellular senescence, epigenetic regulation, and translational therapies for age-related diseases. Her lab explores nuclear lamina dysfunction, inflammation modulation, and drug combinations targeting progerin. Recent studies highlight JAK-STAT inhibition (baricitinib) and synergistic therapies with FTIs, demonstrating efficacy in Progeria mouse models and fibroblasts.
Awards include the Alexander von Humboldt Foundation Fellowship (2009–2014) and Progeria Research Foundation grants. She leads NIH-funded projects (R01, K01) and collaborates on clinical trials using autologous stem cells for skin disorders.
Her lab’s innovations include rapid isolation of skin-derived precursor cells and novel insights into lamin A/C mutations. Ongoing work explores autophagy, metabolic pathways, and botanical compounds for anti-aging applications.
