معرفی
Karen Guldbrandsen serves as a PhD Fellow and Senior registrar at Aalborg University Hospital, where she is embedded within the Department of Gynaecology and Obstetrics under Aalborg University's Faculty of Medicine. Her dual clinical-research role positions her at the critical interface between patient care and translational oncology research, specifically targeting gynaecological malignancies through advanced molecular methodologies.
Her academic foundation comprises a Master of Science in Medicine from Aarhus University (awarded January 5, 2015) followed by specialist certification as a Senior registrar in Obstetrics and Gynaecology from Aalborg University Hospital (awarded April 1, 2022). These qualifications enable her integrated approach to women's health challenges.
Dr. Guldbrandsen's research program intensely focuses on ovarian cancer biomarker discovery using metabolomics and multi-omics platforms. Key thrusts include cell-free DNA methylation profiling for early detection and NMR spectroscopy applications for tumor characterization. Concurrently, she investigates functional outcomes in pelvic floor surgery, examining constipation, incontinence, and patient-defined recovery goals through clinically grounded studies.
Her publication trajectory reveals strategic evolution from foundational clinical work (e.g., tubo-ovarian abscess management, surgical training technology) toward sophisticated molecular oncology. Recent outputs demonstrate increasing sophistication in omics methodologies, with 2024-2025 works establishing cfDNA methylation and NMR as viable diagnostic pathways for gynaecological cancers.
Scientific Awards and Grants:
- Principal Investigator for the externally funded PhD project "NMR spectroscopy and gynaecological cancers - Exploring an emerging method for early diagnosis and prognosis of endometrial and ovarian cancer" (March 1, 2024 - February 28, 2027).
Advising and Research Support: As a doctoral candidate, Dr. Guldbrandsen operates under supervision from Prof. Ulla S. Kesmodel (Obstetrics/Gynaecology), Prof. Inge S. Pedersen (Molecular Medicine), Dr. Han T. T. Nguyen, and Dr. Susanne Lunde. Her primary research capacity derives from her competitively secured PhD project grant, which funds her dual clinical-research appointment.
Collaborative Infrastructure: She actively contributes to the Clinical Cancer Research Center at Aalborg University Hospital and the interdisciplinary Young Omics Cafe network, facilitating cross-departmental biomarker validation studies. These affiliations provide essential frameworks for translating molecular discoveries into clinical practice for gynaecological cancer patients.
