معرفی
Professor Anna deFazio holds the Sydney West Chair in Translational Cancer Research at the Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, with dual appointments in the Department of Obstetrics, Gynaecology and Neonatology and The Westmead Institute for Medical Research. As a leading ovarian cancer researcher, she maintains an extensive international collaboration network spanning Australia, Europe, North America, and Asia.
Her research program integrates cellular/molecular approaches with clinical translational studies focused on gynaecological cancers, particularly ovarian cancer. Key areas include homologous recombination deficiency, treatment resistance mechanisms, cancer genomics, and lifestyle factors affecting cancer survivorship. Professor deFazio employs innovative methodologies including whole genome sequencing, multi-omics analyses, and mathematical modeling of cancer evolution, with particular emphasis on high-grade serous ovarian carcinoma.
Analysis of her recent publications (2023-2025) reveals a sophisticated research portfolio spanning from basic molecular mechanisms to large-scale epidemiological studies. Her work demonstrates consistent focus on genomic drivers of ovarian cancer, treatment resistance mechanisms, and international comparative studies of clinical practices. She frequently leads multi-center collaborations examining genetic, clinical, and lifestyle factors affecting ovarian cancer outcomes, with notable contributions to understanding PARP inhibitor resistance and homologous recombination deficiency.
Professor deFazio actively mentors research students and participates in major initiatives including the Ovarian cancer Prognosis And Lifestyle (OPAL) Study, which examines lifestyle factors and their impact on cancer outcomes. Her laboratory work focuses on understanding the molecular basis of treatment resistance in ovarian carcinoma, while her clinical research examines exercise during chemotherapy, menopausal hormone therapy effects, and international treatment pattern variations.
