K.W. Michael Siu

K.W. Michael Siu is a Full Professor in the Department of Biology at York University, holding the NSERC/MDS SCIEX Chair and serving as Director of the Centre for Research in Mass Spectrometry. His research focuses on advancing proteomics technologies for comprehensive protein identification and sequencing.

• Research Interests
  • Development of mass spectrometry (MS) methodologies for proteomics
  • Study of gas-phase protein/peptide ion formation and structure
  • High-resolution separation strategies for proteome analysis
  • Applications in endometrial cancer biomarkers and Tetrahymena proteomics
  • Phosphorylation site mapping and enhanced phosphopeptide recovery
• Collaborations
  • Dr. Terence J. Colgan (Mount Sinai Hospital) - endometrial cancer
  • Professor Ronald E. Pearlman - Tetrahymena cilia/nucleus proteomes
  • Professor John C. McDermott - phosphorylation analysis
• Scientific Awards
  • NSERC/MDS SCIEX Chair
• Contact
  • Email: kwmsiu@yorku.ca
  • Office: Chemistry Building, Room 244
  • Phone: (416) 650-8021 (Voicemail)

His publications highlight innovations in MS-based sequencing, ion fragmentation pathways, and collaborations to address challenges in cancer biology and cellular proteomics. Current work includes improving phosphopeptide recovery and analyzing complex proteomes.