Justin P. Annes

Justin P. Annes is an Associate Professor at Stanford University's School of Medicine, specializing in Endocrinology, Gerontology, & Metabolism. He directs the Stanford Endocrine Genetics Clinic and contributes to interdisciplinary programs including the Stanford Hypertension Center and Stanford Cancer Institute. His clinical practice focuses on hereditary endocrine disorders such as Multiple Endocrine Neoplasia, Pheochromocytoma, and Hereditary Paraganglioma Syndrome.

• MD/PhD, NYU Grossman Long Island School of Medicine (2004)
• BS, Haverford College (1996)

Dr. Annes' research bridges chemical biology and endocrine disease, with two primary foci: (1) Beta-Cell Regeneration for diabetes therapy using high-throughput chemical screening and (2) Mechanistic studies of Hereditary Paraganglioma Syndrome to understand mitochondrial metabolism-driven oncogenesis. His work on macrophage-derived itaconate revealed novel links between TCA cycle modulation and immune signaling.

Recent publications highlight innovative drug delivery systems (e.g., ultrasonically powered implants, zinc-chelating compounds), genetic variant pathogenicity assessment in endocrine tumors, and inter-organ tumor signaling mechanisms. His Cell Reports study on SDHB/NF1 interactions (2022) challenges established oncometabolite models.

• Stanford Cancer Center Innovation Award (2018)
• NIH R01 Grant (2015-2020)
• Medical Advisory Board, Pheo Para Alliance (2018-)

As a principal investigator, Dr. Annes mentors graduate students and postdoctoral fellows, oversees Stanford's MSTP Admissions Committee, and leads research programs in Cancer Biology and Endocrinology Fellowship. His Annes Laboratory develops chemical tools for beta-cell regeneration and investigates metabolic drivers of neuroendocrine tumors.