Jun Yan

Dr. Jun Yan is a molecular biologist affiliated with the University of Queensland, working within the Department of Medicine as an Honorary Fellow at the UQ Centre for Clinical Research (UQCCR). Her career spans over two decades, with postdoctoral training in the Experimental Oncology laboratory at UQ and subsequent leadership in neuroimmunological studies of autoimmune and neurodegenerative disorders.

• PhD in Molecular Biology, University of Queensland

Since 2001, she has investigated the NF-κB signaling pathway in multiple sclerosis (MS), ischaemic stroke, and amyotrophic lateral sclerosis (ALS). Her work examines how transcriptional dysregulation in inflammation and immunity contributes to disease pathogenesis, including genetic variants, immune cell activation, and hypoxia-related gene expression. Methodologically, she employs flow cytometry, immunohistochemistry, DNA sequencing, and luciferase assays to explore these mechanisms.

Recent publications (2018–2020) highlight her focus on NF-κB subunit regulation in MS progression and hypoxia gene expression in stroke. Collaborative projects with Pamela McCombe, Judith Greer, and Michael Pender have been funded by MS Research Australia. Her research also extends to cytokine dynamics, regulatory T cells, and genetic polymorphisms in autoimmune contexts.

Dr. Yan’s laboratory work within the Neuroimmunology Research group addresses both broad and specific aspects of neurological disease, including transcription factor signaling, immune cell interactions, and biomarker development for disease progression and treatment response.