معرفی
Juliet Goldsmith serves as an Assistant Professor in the Department of Pharmacology, Physiology & Cancer Biology within the College of Life Sciences at Thomas Jefferson University. Her research program investigates fundamental cellular mechanisms with direct implications for neurological and oncological disorders.
Her primary research interests focus on autophagy pathways in neuronal systems, particularly how mitochondrial quality control through autophagosome formation maintains neuronal health. Key investigation areas include:
- Mechanisms of nucleoid-enriched mitochondrial fragment engulfment in neurons
- Compensatory secretory pathways activated during autophagic stress
- Proteomic signatures of neuronal autophagy in neurodegenerative contexts
- Microtubule dynamics modulation for cancer therapeutic enhancement
Dr. Goldsmith's publication record demonstrates expertise spanning neuroscience and cancer biology, with recent work establishing mitochondrial nucleoids as autophagy cargo in neurons (2022) and innovative approaches to cancer therapy through microtubule regulation (2018). Her research bridges fundamental cell biology with translational applications for neurodegenerative diseases and oncology.
She leads the Goldsmith Laboratory at the Bluemle Life Sciences Building, where her team employs advanced proteomic and cellular imaging techniques to dissect neuronal maintenance pathways. Current investigations focus on the intersection of autophagy dysregulation and neurodegenerative disease progression.
