معرفی
Dr. Julie McDonald is a Senior Lecturer at Imperial College London's Department of Life Sciences (Faculty of Natural Sciences), leading the Centre for Bacterial Resistance Biology. Her research focuses on gut microbiota-mediated colonization resistance against multidrug-resistant organisms (MDROs), particularly investigating mechanisms like nutrient competition and metabolite inhibition. She employs artificial gut models (e.g., chemostats), omics techniques, and human faecal samples to develop microbiome therapeutics.
Dr. McDonald holds a PhD in Molecular and Cellular Biology (University of Guelph, 2013) and a BSc in Biochemistry (University of Guelph, 2009). Her affiliations include the Microbiome Network, Institute of Infection, and Antimicrobial Research Collaborative. She investigates MDRO intestinal reservoirs, antibiotic-induced dysbiosis, and microbiota restoration strategies for decolonization. Her lab also explores bile acid metabolism in cholestasis and links between microbiota and conditions like psoriatic arthritis.
- Affiliations:
- Centre for Bacterial Resistance Biology
- Institute of Infection
- Antimicrobial Research Collaborative
- Microbiome Network
Key research themes include:
- Antimicrobial resistance mechanisms
- Microbiome therapeutics
- Bacterial pathogenesis
- Host-microbe metabolic interactions
Her publications highlight advancements in understanding MDRO colonization, fecal microbiota transplantation efficacy, and microbiome-driven disease mechanisms. Current work emphasizes translational applications of microbiome research to combat antibiotic resistance and improve clinical outcomes.
