معرفی
Jun.-Prof. Dr. Juliane Bremer serves as an Assistant Professor and group leader at the Department of Neuropathology, University Hospital Aachen (RWTH Aachen University), where she also works as an attending physician specializing in neuropathological diagnostics and research.
Her academic foundation includes medical training and a PhD from the University Hospital Zürich under Prof. Adriano Aguzzi, followed by postdoctoral research at the University of Pennsylvania with Prof. Michael Granato. This multidisciplinary background bridges clinical neuropathology with molecular neuroscience.
Dr. Bremer's research program centers on zebrafish models of neuromuscular diseases, integrating CRISPR/Cas9 gene editing, transgenesis, spinning disc confocal microscopy, and compound library screening to investigate ALS, hereditary peripheral neuropathies, and muscle disorders. Her team examines how disease-causing mutations disrupt nerve and muscle development, maintenance, and regeneration, with direct clinical correlations to patient pathology.
Analysis of her 15 most recent publications reveals three dominant research thrusts: molecular mechanisms of axon regeneration (using zebrafish nerve injury models), prion disease pathophysiology (including metabolic disruptions in skeletal muscle), and neuro-oncological applications (spatial transcriptomics of nerve sheath tumors). Her work consistently bridges basic science with clinical neuropathology.
Dr. Bremer actively mentors doctoral researchers and secured competitive DFG funding in 2022 for a spinning disk confocal microscope with ablation/FRAP capabilities. Her laboratory team comprises medical doctoral students (Yan Feng, Xiaomeng Zhang), a PhD candidate (Martin Groß), and technical staff (Tayfun Palaz), reflecting an integrated clinical-research environment focused on neuromuscular disease mechanisms.
