معرفی
Judith Sleeman is a Senior Lecturer at the University of St Andrews, affiliated with the School of Biology, Centre for Biophotonics, Biomedical Sciences Research Complex, and Institute of Behavioural and Neural Sciences. Her research focuses on RNA processing in mammalian cells and its impact on human disease, with particular expertise in neuromuscular disorders.
Dr. Sleeman's research interests center on the physical organization of RNA processing in mammalian cells and its implications for human disease. Her work spans from fundamental cellular organization of splicing snRNP maturation to cytoplasmic transport of mRNA and the effects of triplet repeat disorders on cellular structure. Current projects investigate the cellular and molecular basis of Spinal Muscular Atrophy, Myotonic Dystrophy Type 1, and Amyotrophic Lateral Sclerosis using advanced techniques including live-cell and high-resolution microscopy and proteomics.
Analysis of Dr. Sleeman's publication record reveals a strong focus on RNA biology, nuclear organization, and neuromuscular disorders. Her research demonstrates a progression from fundamental studies of nuclear bodies to disease mechanisms, with increasing emphasis on therapeutic applications for genetic neuromuscular conditions. Recent work shows particular attention to stress granules, RNA metabolism in disease contexts, and molecular mechanisms underlying triplet repeat disorders.
Scientific awards include:
- British Society for Cell Biology 'Young Cell Biologist of the Year' (1995)
- FRSB (Fellowship of the Royal Society of Biology) (2014)
- Oxford Gene Technologies 'Proof of Principle Micro-array Study' competition (2005)
Dr. Sleeman has supervised multiple students and researchers, with five supervised works documented. She has secured significant grant funding from prestigious organizations including The Wellcome Trust, Motor Neurone Disease Scotland, and BBSRC. Her projects include 'Protein methylation as a mechanism for cellular damage in motor neurone disease' (£136,298), 'Judith Sleeman Studentship ISSF3' (£35,000), and 'Advanced integrative mass spectrometer' project with BBSRC funding.
The Sleeman lab operates within the Biomedical Sciences Research Complex at St Andrews, utilizing advanced microscopy and proteomics facilities. The lab has attracted visits from prominent figures including Diana, Countess Lindsay, and has generated media coverage for breakthroughs in understanding genetic causes of infant death. Research in the lab contributes to UN Sustainable Development Goals related to health and well-being.
