معرفی
Judith Klein-Seetharaman is a Professor at Arizona State University (ASU), jointly appointed in the School of Molecular Sciences and the College of Health Solutions. Her research integrates computational and experimental approaches to study protein structure, dynamics, and function, with a focus on membrane proteins and their roles in health and disease.
Education:
- PhD from MIT, advised by Nobel Laureate Har Gobind Khorana, studying rhodopsin conformational changes.
- Undergraduate degrees in Biology and Chemistry from the University of Cologne, Germany.
Research Interests: Her work spans structural biology, computational modeling, and systems biology. Key areas include:
- Membrane protein dynamics, particularly GPCRs and insulin receptors.
- Environmental and biomedical applications, such as coral microbiome resilience and asphalt toxicity.
- Protein interactions and drug discovery, including SARS-CoV-2 human interactome studies.
Articles Trends: Recent work highlights interdisciplinary projects, such as coral signaling pathways, neurotoxic effects of asphalt emissions, and ferroptosis suppression mechanisms. These studies leverage structural biology, bioinformatics, and systems-level analyses to address complex biological questions.
Awards:
- NSF CAREER Award for integrating teaching and research on membrane receptor evolution.
- Margaret Oakley Dayhoff Award for computational biology contributions.
- Bill and Melinda Gates Foundation Grant for HIV drug target discovery.
Advising & Grants: Mentored over 20 graduate students, including interdisciplinary projects in computational biology and biophysics. Active in industry collaborations, including CEO roles in Sarkar-Klein-Labs LLC and Neosensations LLC.
Labs/Teams: Leads research groups in structural discovery and health solutions, collaborating with institutions like the Biodesign Center for Applied Structural Discovery and the Arizona Alzheimer's Consortium.
