معرفی
Alan M. Grossfield is an Associate Professor in the Department of Biochemistry and Biophysics, specializing in computational modeling of biological systems. His research focuses on lipid-protein interactions, G protein-coupled receptors (GPCRs), and antimicrobial peptides, using molecular dynamics simulations to investigate structure, thermodynamics, and function. Collaborations with experimental groups enhance his work on rhodopsin activation mechanisms and drug development.
His research interests include understanding how lipids modulate protein function, particularly in GPCRs like rhodopsin, and developing computational tools (e.g., LOOS) for analyzing molecular dynamics data. He also studies antimicrobial lipopeptides' mechanisms and their selective targeting of microbial membranes.
Recent work involves time-resolved X-ray scattering to study rhodopsin activation dynamics and free energy calculations for RNA-small molecule complexes. He explores nitrosyl factors' role in opioid-related respiratory depression and investigates mitochondrial responses to hypoxia in C. elegans.
Grossfield’s contributions span over 70 publications, with emphasis on membrane biophysics, drug discovery, and computational methodology. He collaborates with experts in structural biology, pharmacology, and terahertz spectroscopy to bridge theory and experiment.
