Josephine Skat-Rørdam

Josephine Skat-Rørdam serves as a Postdoctoral Research Fellow within the Graduate Programme for In Vivo Pharmacology and Experimental Animals at the Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen. Her research focuses on modeling human metabolic diseases using guinea pig models, with particular emphasis on non-alcoholic fatty liver disease (NAFLD) and its systemic complications.

• Molecular Biomedicine, University of Copenhagen (PhD Awarded September 1, 2016)

Her primary research investigates the pathophysiology of NAFLD progression to steatohepatitis (NASH), examining how dietary components, vitamin deficiencies, and pharmacological interventions influence liver metabolism, cardiovascular complications, and disease regression. Current work explores transcriptomic similarities between guinea pig models and human NAFLD, diagnostic imaging validation, and the interplay between nutritional factors and metabolic dysfunction. Her experimental approach integrates in vivo pharmacology with molecular analysis to identify therapeutic targets.

Recent publications reveal consistent focus on guinea pig models as translational tools for NAFLD research, with trends emphasizing dietary modulation of disease progression, antioxidant effects on cardiovascular comorbidities, and validation of preclinical methodologies. Key themes include metabolic imaging, nutrient-gene interactions, and pharmacological interventions targeting inflammation and fibrosis.

• LIFEPHARM PhD Fellowship

Her research is supported through the LIFEPHARM centre collaboration, with extensive external partnerships across European institutions focused on metabolic disease modeling. While specific grant details aren't provided, her high-impact publications (including a 2019 review with 163 Scopus citations) demonstrate significant contribution to the field. Current work continues through the Preclinical Disease Biology group within the Department of Veterinary and Animal Sciences.

Dr. Skat-Rørdam operates within the Graduate Programme for In Vivo Pharmacology and Experimental Animals, utilizing specialized guinea pig models to study NAFLD pathogenesis. Her team collaborates extensively with researchers across Scandinavia on metabolic disease mechanisms, maintaining facilities for controlled dietary studies and advanced phenotypic characterization of liver and cardiovascular pathologies.