Joseph Sodroski

Joseph Sodroski is a Professor of Microbiology at Harvard Medical School and affiliated with the Dana-Farber Cancer Institute. His research focuses on HIV-1 entry mechanisms, particularly the role of viral envelope glycoproteins in membrane fusion and cellular infection. Key interests include understanding conformational transitions of glycoproteins, developing inhibitors, and investigating cytopathic effects of envelope expression in host cells.

He leads a lab studying HIV transmission dynamics, small-molecule entry inhibitors, and neutralizing antibodies. His work also addresses SARS-CoV-2 spike glycoprotein properties. Affiliations include the Division of Medical Sciences at Harvard Medical School and Harvard Integrated Life Sciences networks.

• Research Interests: HIV virology, antiviral drug discovery, viral entry mechanisms
• Lab Location: Dana-Farber Cancer Institute, Boston
• Key Techniques: Structural biology, molecular virology, antibody engineering

Publications (selected): Analyzes HIV/SARS-CoV-2 glycoprotein structures, CD4-mimetic compounds, and antibody-dependent cytotoxicity mechanisms. Recent work includes 2024 studies on pretriggered HIV envelope conformations and 2023 research on SARS-CoV-2 variant spike proteins.

Awards: Not explicitly listed in provided materials.

Lab Team: Collaborates with virologists, immunologists, and structural biologists. Supervises postdoctoral fellows and graduate students through Harvard's microbiology and immunology programs.