Joseph N Paulson

Joseph N Paulson is an Adjunct Assistant Professor in the Department of Neurosurgery at the Yale School of Medicine. He holds a PhD in Applied Mathematics, Statistics, and Scientific Computation from the University of Maryland, College Park (2015). His research focuses on integrating computational methods with clinical and microbial genomic studies to address complex medical challenges. Key areas of investigation include microbial pathogenesis (e.g., Paenibacillus infections in pediatric hydrocephalus), cancer genomics (e.g., lymphoma prognosis and treatment response), and the development of bioinformatics tools for microbiome and transcriptomic analysis.

Dr. Paulson’s work bridges disciplines such as computational biology, infectious diseases, and oncology. He leads collaborative projects analyzing microbial communities in clinical settings, including vaginal microbiome dynamics and bacterial virulence mechanisms. His computational tools, like mbQTL and the Network Zoo package, enable advanced microbiome QTL analysis and gene regulatory network modeling. He also contributes to clinical trials evaluating targeted therapies in breast and blood cancers, leveraging genomic signatures for personalized treatment strategies.

Notable contributions include identifying Paenibacillus as a novel pathogen in Ugandan infants with post-infectious hydrocephalus and developing prognostic models for diffuse large B-cell lymphoma using imaging and genomic data. His research emphasizes global health applications, particularly in pediatric neurosurgery and infectious disease epidemiology.