Joseph Minhow Chan

Joseph Minhow Chan is a Clinical Assistant Professor and Assistant Attending in the Department of Medicine at Memorial Sloan Kettering Cancer Center, actively contributing to the Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center and Human Oncology and Pathogenesis Program. His research bridges clinical oncology and molecular tumor biology, with a focus on aggressive cancers.

His primary research interests include:

• Small Cell Lung Cancer and Neuroendocrine Tumor Biology
• Molecular Subtyping and Tumor Heterogeneity (e.g., ATOH1 subtype)
• Metastasis Mechanisms in Tumor Ecosystems
• DNA Damage Response Pathways (ATR, CDC7 inhibition)
• Immunotherapy Resistance and cGAS/STING Signaling
• MYC-Driven Oncogenic Transformation

Recent publications (2024–2025) reveal a concentrated effort on small cell lung cancer, investigating how molecular subtypes drive metastasis, how ATR inhibition activates antitumor immunity via interferon signaling, and the role of CDC7/MYC in neuroendocrine transformation across lung and prostate cancers. These studies highlight therapeutic vulnerabilities in treatment-resistant tumors.

No scientific awards were documented in the available sources.

While no advising or grant details were specified, his extensive co-authorship network (including Rudin, Quintanal-Villalonga, and Sen across 32+ MSK collaborators) indicates active mentorship and team-based research within MSK’s collaborative ecosystem.

Dr. Chan operates within MSK’s specialized research infrastructure, particularly the Metastasis and Tumor Ecosystems Center, which examines dynamic interactions between cancer cells and their microenvironment. His work leverages institutional resources like the Human Oncology and Pathogenesis Program to translate molecular insights into clinical strategies for metastatic disease.