معرفی
Dr. Joseph P. Kao is a Professor in the Department of Pharmacology & Physiology at the University of Maryland School of Medicine. His research focuses on the design, synthesis, and application of molecular probes for studying physiological functions in biological systems, including fluorescent molecules and photosensitive 'caged' compounds for optical control, as well as spin probes and isotopically substituted metabolites for magnetic resonance imaging modalities like EPRI and hMRI.
Education and Training
- B.S. in Chemistry from Arizona State University (1978)
- Ph.D. in Chemistry from University of California, Berkeley (1985)
- Postdoctoral Research in Cell Biology and Physiology at University of California, Berkeley (1989)
- Postdoctoral Research in Cell Biology and Physiology at University of California, San Diego (1990)
Research Focus
Dr. Kao's work bridges optical microscopy and magnetic imaging modalities, enabling precise monitoring and manipulation of cellular physiology and neurophysiology. His fluorescent probes are widely used in cell biology and neurophysiology, while spin probes and hMRI techniques advance preclinical and potential clinical studies.
Recent Publication Trends
Dr. Kao's recent articles highlight advancements in redox biology and metabolic imaging. They explore electron paramagnetic resonance (EPR) for redox status measurement in acute lung injury, superoxide-based RBC storage quality probes, and novel spin probe designs for prolonged intracellular retention.
Patents and Innovations
Dr. Kao has contributed to numerous patents, including technologies for light-activated molecule release, caged amino acid derivatives, and targeted delivery of imaging probes via immunoliposomes.
