معرفی
Joseph A. Bonanno is a Professor and Dean Emeritus at Indiana University School of Optometry, where he continues his research in corneal physiology and teaches biochemistry and physiology to optometry students. He has maintained a distinguished academic career spanning several decades, with significant contributions to understanding corneal endothelial function and ocular physiology.
Education:
- B.A. in Biology from University of Pennsylvania (1975)
- M.S. in Molecular Biology (1977)
- O.D. from University of California, Berkeley (1981)
- Ph.D. in Physiological Optics from University of California, Berkeley (1987)
Dr. Bonanno's research focuses primarily on corneal physiology, with special emphasis on ion transport mechanisms in the corneal endothelium, corneal hydration regulation, and the metabolic processes that maintain corneal transparency. His work has significantly advanced our understanding of how the corneal endothelium functions as a pump to maintain proper hydration levels in the cornea, which is essential for clear vision. He has investigated the role of specific transporters like SLC4A11, lactate:H+ co-transporters, and their interactions with bicarbonate and carbonic anhydrase. His research has important implications for understanding and treating corneal edema and other corneal disorders.
Analysis of Dr. Bonanno's recent publications reveals a consistent focus on molecular mechanisms of corneal endothelial function, with particular attention to ion transport systems, metabolic regulation, and the cellular basis of corneal transparency. His work bridges basic science with clinical applications, especially in understanding how contact lens wear affects corneal physiology and how various transporters maintain corneal hydration.
Professional Recognition:
- Fellow of the American Academy of Optometry
Dr. Bonanno has held significant leadership positions including Associate Dean for Research (2005-2007), Associate Dean for Academic Affairs and Student Administration, and Dean of the IU School of Optometry (2010-2023). He teaches Integrative Optometry (V 501 and V 502), Systems Approach to Biomedical Sciences, Biochemistry (V 542 and V 543), and Ocular Biology (V 540). His ongoing research projects include investigating the role of SLCA411 in corneal endothelial function, modulation of corneal endothelial mitochondrial activity by estrogen, and evaluation of lactate:H+ co-transporters.
His laboratory continues to be a center for innovative research in corneal physiology, with particular expertise in electrophysiological techniques, molecular biology approaches to study ion transport, and metabolic analyses of corneal tissue. The research team investigates both fundamental mechanisms of corneal function and potential therapeutic applications for corneal disorders.
