Joscha Rombach

Joscha Rombach serves as a Guest Researcher in the Department of Biomedical Sciences at the Faculty of Health and Medical Sciences, University of Copenhagen, affiliated with the Inflammation, Metabolism and Oxidation research group. His work bridges molecular neuroscience and metabolic disease mechanisms through advanced cellular and molecular techniques.

Rombach's research centers on protein-membrane interactions in neurological and metabolic disorders, with emphasis on GPCR trafficking, neuropeptide signaling (particularly NPY), and scaffold protein functions (notably PICK1). His investigations span insulin granule biogenesis in diabetes, chronic pain pathways, and novel biosensor development for real-time neurotransmitter detection, employing cutting-edge approaches like GRAB sensors and membrane curvature analysis.

Analysis of his recent publications reveals a cohesive focus on molecular determinants of disease, where protein domain functions (BAR domains, amphipathic helices) are systematically linked to pathological outcomes in diabetes and pain. His collaborative work demonstrates strong translational potential through structural biology insights applied to therapeutic target validation.

Rombach operates within the Inflammation, Metabolism and Oxidation research ecosystem at the University of Copenhagen, engaging in multidisciplinary collaborations with neuroscientists, endocrinologists, and structural biologists to dissect disease mechanisms at the molecular level.