معرفی
Professor Jonathon Pines is the Chris Marshall Chair of Cell Biology at The Institute of Cancer Research (ICR), University of London, and serves as Head of the Division of Cancer Biology. Since moving to ICR in 2015, he has led a research programme focused on understanding how cells divide and how the machinery controlling mitosis is regulated in space and time.
Education & Career:
- PhD under Sir Tim Hunt—first to clone cyclin B, a key regulator of mitosis.
- Postdoctoral training at the Salk Institute in Tony Hunter’s lab—cloned first human cyclins A and B1 and initiated studies on cell-cycle protein interactions.
- Established independent laboratory at the Gurdon Institute, University of Cambridge, pioneering live-cell imaging of fluorescent protein dynamics to study cell-cycle regulation.
Research Focus:
His group investigates the spatial and temporal control of mitosis, with particular emphasis on the spindle assembly checkpoint, APC/C ubiquitin ligase, cyclin degradation, and the maintenance of genomic stability. Recent work explores how spatial positioning of APC/C and cyclin B1 on mitotic chromosomes ensures timely proteolysis and accurate chromosome segregation.
Scientific Recognition:
- Elected Fellow of the Royal Society (2016) for outstanding contributions to cell-cycle research.
Funding & Collaborations:
His research has been supported by major grants and extensive national and international collaborations, reflected in co-authored studies across proteomics, structural biology, and live-cell imaging.
Laboratory & Team:
The Pines laboratory, located in Chelsea, London, integrates advanced microscopy, biochemical reconstitution, and quantitative proteomics to dissect the molecular choreography of mitosis and its implications for cancer biology.
