معرفی
Jonathan Schertzer is a Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University's Faculty of Health Sciences. He holds a prestigious Canada Research Chair in Metabolic Inflammation and is an active member of both the Centre for Metabolism, Obesity, and Diabetes Research (MODR) and the Farncombe Family Digestive Health Research Institute. His research program examines the intricate connections between metabolism, immunity, and gut microbiota, with significant implications for understanding and treating obesity, diabetes, fatty liver disease, and related metabolic disorders.
Dr. Schertzer's research interests focus on how nutrients, microbiota, and drugs engage the immune system to alter endocrine control of metabolism. His work spans immunometabolism, host-microbe interactions, and the molecular mechanisms linking inflammation to metabolic dysfunction. His studies often explore the role of pattern recognition receptors like NOD1 and NOD2 in metabolic regulation and inflammation.
His publications reveal a strong emphasis on the gut microbiome's role in metabolic health, with particular attention to how microbial metabolites influence host physiology. Recent work has examined D-lactate metabolism, postbiotics, intermittent fasting effects in metabolic disease, and the impact of food additives on gut microbiota and metabolic health. His research demonstrates how bacterial components and metabolites can directly influence host metabolic pathways and inflammatory responses.
- Canada Research Chair in Metabolic Inflammation
Dr. Schertzer actively mentors students through senior thesis projects and teaches courses including Biochemical Membranes (BIOCHEM 6M03) and Cellular and Integrated Metabolism (BIOCHEM 4M03). His laboratory investigates how metabolic inflammation develops during obesity and how this process can be targeted therapeutically through modulation of the gut microbiome, host immune receptors, and metabolic pathways.
