معرفی
Jonathan Kirk, PhD, is a Professor and Vice Chair in the Department of Cell and Molecular Physiology at Loyola University Chicago's Stritch School of Medicine. His work focuses on understanding how sarcomere dysfunction drives cardiovascular diseases like heart failure and diabetes. The Kirk lab employs proteomics (e.g., mass spectrometry) and biophysical assays to study myofilament protein modifications and their therapeutic implications.
Education:
- BS in Bioengineering, Washington State University (2004)
- PhD in Bioengineering, University of Pittsburgh (2009)
Research Focus: The lab investigates mechanisms linking sarcomere remodeling to heart failure, including dyssynchrony, ischemia, and genetic mutations. Key areas include myofilament proteomics, calcium signaling, and the role of BAG3 in protein turnover. Recent work explores Cardiac Resynchronization Therapy (CRT) mechanisms and novel treatments for diabetic cardiomyopathy.
Lab Activities: The lab uses advanced techniques like single-cell calcium assays and cryopreservation to study human and animal myocardial samples. They collaborate extensively within the Department of Cell and Molecular Physiology to leverage cutting-edge proteomic tools.
