Jonathan Goldberg

Jonathan Goldberg, PhD, holds the Stephen and Barbara Friedman Chair at the Structural Biology Program, Memorial Sloan Kettering Cancer Center. His research focuses on endoplasmic reticulum (ER) protein trafficking and quality control mechanisms.

• Academic Rank: Professor (Stephen and Barbara Friedman Chair)
• Education: PhD from Imperial College (London)

Research Interests: The lab investigates COPII machinery for ER-derived vesicle synthesis, mechanisms of cargo protein sorting, and cellular responses to ER proteotoxicity in neurodegenerative disorders (Parkinson's disease), cancer, and metabolic diseases (insulin resistance). Key studies examine 4-phenylbutyrate's role in regulating ER retention processes.

Publication Trends: Recent work (2013-2017) emphasizes structural characterization of COPII coat assembly, dilysine motif recognition, and pharmacological modulation of ER quality control systems using 4-PBA and analogs.

Lab Members: Current research team includes Guoqi Niu, Shun Zhao, Chen Li, Wenfu MA, and Denise Ramirez. Alumni members are Gabriella Angiulli (Research Fellow), Taylor Manett (Research Technician), and Narcisa Martinez (Research Fellow).