Jonatha M. Gott

Jonatha M. Gott is a Professor in the Department of Biochemistry at the School of Medicine, Case Western Reserve University, and a member of the Center for RNA Science and Therapeutics. Her research is centered on RNA editing, particularly in the mitochondrial system of the slime mold Physarum polycephalum, where she investigates the molecular mechanisms of nucleotide insertion, deletion, and base conversion in RNA transcripts.

Research Interests: Dr. Gott's work explores how RNA sequences are altered post-transcriptionally without changes to the genomic DNA. Her lab focuses on co-transcriptional RNA editing, identifying the proteins involved in editing complexes, and developing in vitro systems to dissect the biochemical steps. Her research has broad implications for understanding gene expression, mitochondrial function, and RNA-based diseases.

The most recent articles reflect a strong focus on RNA editing mechanisms across diverse organisms, mitochondrial transcriptomics, tRNA processing, and the evolutionary aspects of RNA modification. Key trends include the discovery of novel editing factors, the role of Thg1-like enzymes, and the use of deep sequencing to characterize edited transcriptomes.

Scientific Awards:

• No awards explicitly mentioned in the text.

Advising and Grants: While specific students and grants are not listed, Dr. Gott has supervised research leading to numerous publications and has contributed to major scientific resources such as the Methods in Enzymology series. She likely mentors graduate students and postdoctoral researchers in molecular biology and RNA biochemistry.

Labs and Teams: Dr. Gott leads a research team focused on RNA editing mechanisms and is affiliated with the Center for RNA Science and Therapeutics at Case Western Reserve University, fostering interdisciplinary collaboration in RNA biology and therapeutic development.