معرفی
Jonas Muhr is a Professor at the Department of Cell and Molecular Biology, Karolinska Institutet, where he leads the Stem Cell Biology group. His research focuses on understanding how brain stem cells are regulated during cortical development and prevented from malignant transformation. Muhr holds a Docent title from Karolinska Institutet (2012) and has been active in the field since 2001, contributing to over 30 peer-reviewed articles.
Research Interests
His work spans molecular mechanisms of neural progenitor regulation, SOX transcription factor networks, and the interplay between cell cycle control and differentiation. Key topics include tumor suppression in stem cells, developmental signaling pathways (e.g., Notch, Shh), and chromatin accessibility in neural development.
Recent Trends in Publications
Publications emphasize SOX protein functions (e.g., SOX2, SOX6, SOX21), cyclin-CDK regulatory circuits, and myeloid cell roles in cancer immunology. Studies often integrate molecular genetics with in vivo models to dissect neural lineage decisions and oncogenesis.
Laboratory & Teams The Stem Cell Biology group collaborates extensively on projects involving brain development, stem cell plasticity, and translational cancer research. The group’s work bridges basic biology and clinical applications, particularly in glioma and pheochromocytoma pathogenesis.
