John Sheridan

Dr. John Sheridan is a Professor at The Ohio State University, holding a joint appointment in the Department of Oral Biology and Behavioral Neuroscience area. His research focuses on neuroimmune interactions following traumatic stress, with emphasis on understanding mechanisms underlying post-traumatic stress disorder (PTSD), neuropsychiatric sequelae, and chronic pain. His work integrates translational approaches using both human and rodent models. Key areas include neuroinflammation, stress resilience, and the impact of social/environmental factors on brain function.

Dr. Sheridan has conducted longitudinal studies like the AURORA study, analyzing trauma survivors' brain biology and functional outcomes. His research explores biomarkers such as heart rate variability and C-reactive protein, as well as genetic and neuronal signaling pathways (e.g., IL-1R1, microglial activity) involved in stress responses. He examines how early life adversity and social stress affect neurobiological trajectories, linking these to clinical outcomes like PTSD, depression, and pain syndromes.

Publications highlight interdisciplinary methods, including advanced imaging, wearable technologies, and genomic analysis. His work addresses translational challenges in developing predictive models and interventions for trauma-related disorders.