John O'Doherty

John O'Doherty is the Fletcher Jones Professor of Decision Neuroscience at the California Institute of Technology (Caltech). He holds a B.A. from Trinity College Dublin (1996) and a D.Phil. from the University of Oxford (2000). His academic trajectory includes roles as Assistant Professor (2004–2007), Associate Professor (2007–2009), and Professor (2009–present), culminating in his current endowed chair since 2021. From 2013–2017, he served as Director of the Caltech Brain Imaging Center.

Research Focus: O'Doherty’s work investigates how the brain processes decisions under uncertainty, encodes reward values, and learns from experience. His group studies neural systems involved in decision-making, including arbitration between model-based and model-free learning strategies, the role of prefrontal and striatal circuits in value representation, and social learning mechanisms. They utilize computational modeling combined with neuroimaging (fMRI) and electrophysiological techniques.

Key Contributions: His research bridges cognitive neuroscience and psychiatry, addressing topics like gambling disorder, autism spectrum traits, anorexia nervosa, and obsessive-compulsive behaviors. He has pioneered studies on the neural substrates of reward prediction errors, hierarchical decision-making, and the interplay between habitual and goal-directed actions.

Affiliations:

• Caltech Brain Imaging Center (Former Director)
• Leading international collaborations in neuroeconomics and computational psychiatry

Grants & Funding: Extensive support from NIH, NSF, and private foundations for projects on decision neuroscience and translational mental health research.